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Ketamine/SPRAVATO® Management

SPRAVATO® (esketamine) at reVIBE Mental Health

A monitored, in-office treatment option for adults with hard-to-treat depression.

If you’ve tried multiple antidepressants and still feel stuck—or if depression symptoms feel urgent and overwhelming—SPRAVATO® may be an option worth exploring. reVIBE Mental Health offers structured, supervised SPRAVATO treatment sessions and a plan that supports you before, during, and after each visit.

Schedule a SPRAVATO consultation

What is SPRAVATO®?

SPRAVATO® (esketamine) is a prescription nasal spray used for certain adults with depression. It’s administered in a certified healthcare setting and is typically used alongside an overall treatment plan that may include medication management and therapy.

SPRAVATO is approved for:

  • Treatment-resistant depression (TRD) in adults (as monotherapy or with an oral antidepressant)
  • Depressive symptoms in adults with major depressive disorder (MDD) with acute suicidal ideation or behavior, used with or without an oral antidepressant Spravato REMS+1

Who may be a good candidate?

SPRAVATO may be appropriate if you:

  • Have tried two or more antidepressants without adequate relief
  • Have symptoms that significantly impact work, relationships, sleep, or daily functioning
  • Need a treatment approach that works differently than standard oral antidepressants

During your evaluation, our team will review your history, current medications, medical considerations, and safety factors to determine whether SPRAVATO is a fit.

How SPRAVATO works (in plain language)

SPRAVATO acts on the brain’s glutamate system and affects the NMDA receptor, which is different than how many traditional antidepressants work. Spravato REMS+1
Some patients notice changes sooner than they have with prior treatments, but response varies—and we’ll set expectations clearly based on your situation.

What treatment looks like at reVIBE Mental Health

SPRAVATO is not a “pick up at the pharmacy and use at home” medication. Each session is structured for safety and support:

  1. Arrival + check-in (including vitals and symptom check)
  2. Self-administer SPRAVATO under direct clinical supervision
  3. On-site monitoring for at least 2 hours
  4. Safe Transportation home.

Most patients start with more frequent visits and taper over time based on response and provider guidance (your plan is individualized).

Important safety requirements (REMS + monitoring)

SPRAVATO is available only through a restricted safety program (REMS) and must be given in a certified healthcare setting. Spravato REMS+1

Because of risks that can include sedation, dissociation, and blood pressure increases, patients must be monitored after each dose and are evaluated before leaving.

How to prepare for your appointment

To help your session go smoothly, plan for:

  • A ride home (you cannot drive yourself after treatment) 
  • Something relaxing for the observation period (headphones, playlist, book)

 

Following pre-visit instructions from our team, which may include guidance about food and drink and timing of certain nasal medications.

Better outcomes come from a whole plan, not one tool

SPRAVATO often works best when it’s part of a broader treatment approach. Depending on your needs, your plan at reVIBE Mental Health may include:

  • Medication management (including optimizing oral antidepressants when appropriate)
  • Individual therapy to build coping strategies and relapse prevention skills
  • Other evidence-based options when clinically appropriate
  • Should be Empty:

Frequently asked questions

How soon will I feel a difference?

Some people report improvement early, while others need multiple sessions before noticing meaningful change. We track symptoms and adjust your plan based on data—not guesswork.

Will I be asleep or “out of it”?

Some patients experience sedation or a detached/dissociative feeling during the session, which is one reason monitoring is required. 

Can I drive after treatment?

No—plan for a ride home. You’ll be discharged only when clinically stable, and driving is not permitted after dosing. 

Is SPRAVATO the same as ketamine infusions?

They are different treatments. SPRAVATO is FDA-approved esketamine nasal spray delivered under REMS requirements in-office. Spravato REMS+1

Take the next step

If you’re ready to explore whether SPRAVATO is right for you, reVIBE Mental Health can help you understand eligibility, timeline, and coverage considerations.

Call or Text reVIBE Mental Health
Request a SPRAVATO Consultation Online
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Where can I find a Clinic Near Me?

We currently have five locations for your convenience

reVIBE Mental Health - Chandler

3377 S Price Rd, Suite 105, Chandler, AZ

reVIBE Mental Health - Phoenix Deer Valley

2222 W Pinnacle Peak Rd, Suite 220, Phoenix, AZ

reVIBE Mental Health - Phoenix PV

4646 E Greenway Road, Suite 100, Phoenix, AZ

reVIBE Mental Health - Scottsdale

8700 E Via de Ventura, Suite 280, Scottsdale, AZ

reVIBE Mental Health - Tempe

3920 S Rural Rd, Suite 112, Tempe, AZ

Insurance Verification

We accept most insurance plans. Don’t see your insurance listed? 

Contact For Insurance Verification
(480) 674-9220
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At reVIBE, you can access therapy and licensed medication support in person or online throughout Scottsdale, Tempe, Chandler, Deer Valley, Phoenix, and Paradise Valley.

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